| 名稱 | PDGFRA D842V-T674I/BaF3 kinase細(xì)胞株 |
| 型號 | CBP73335 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | PDGFRA D842V-T674I/BaF3 |
產(chǎn)品搜索
相關(guān)文章
- 假病毒標(biāo)準(zhǔn)品
- 【新品上線】多重病原菌質(zhì)控品
- 【藥靶模型】ESR1 Y537S模型開發(fā)
- 【現(xiàn)貨上線】HRR-Related-28 Gene標(biāo)準(zhǔn)品
- PNAS：腫瘤細(xì)胞或可“拆用”間充質(zhì)干細(xì)胞來促進(jìn)乳腺癌復(fù)發(fā)
- 【靶點(diǎn)模型+診斷質(zhì)控】c-Kit常見突變的藥物開發(fā)和診斷
- PIK3CA診斷標(biāo)準(zhǔn)品
- GABA細(xì)胞篩選模型
- 北京細(xì)胞庫關(guān)于細(xì)胞存儲的意義了解下
- 鑒別出促進(jìn)黑色素瘤進(jìn)展的關(guān)鍵蛋白,開發(fā)出新型癌癥靶向療法
聯(lián)系我們
聯(lián)系人：蔣經(jīng)理
電話：4008750250
號碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com
電話：4008750250
號碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com
產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73335PDGFRA D842V-T674I/BaF3 kinase細(xì)胞株
- 詳細(xì)內(nèi)容
| CBP73335 | |
| I. Introduction | |
Cell Line Name： | PDGFRA D842V-T674I/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
PDGFRA D842V lies within the protein kinase domain of the Pdgfra protein (UniProt.org). D842V results in ligand-independent phosphorylation of Pdgfra, activation of downstream signaling, and is transforming in culture (PMID: 22745105, PMID: 23752188, PMID: 29533785, PMID: 30253204) and confers resistance to PDGFRA inhibitors (PMID: 30389923, PMID: 18955458). | |
| III. Representative Data | |
1.Sanger of PDGFRA D842V-T674I/BaF3
Figure 1. PDGFRA D842V-T674I/BaF3 T674I
Figure 2. PDGFRA D842V-T674I/BaF3 D842V | |
2. Anti-proliferation assay | |
Figure 3. CTG Proliferation Assay of BaF3 PDGFRA D842V/T674I Cells (C4). | |
