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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74148Claudin18.2/NCI-N87

Claudin18.2/NCI-N87
名稱 Claudin18.2/NCI-N87
型號 CBP74148
報價
特點 NCI-N87
  • 詳細(xì)內(nèi)容
CBP74148
I. Background

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.


II. Introduction
Host Cell:NCI-N87
Expressed gene:

Claudin18.2

Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Culture Medium:RPMI-1640+10%FBS+2ug/ml puromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Binding Assay,FACS

III. Description of Host Cell Line
Species:Homo sapiens, human
Tissue:Stomach; derived from metastatic site: liver
Disease: Gastric carcinoma
Morphology: Epithelial
Growth Properties: Adherent

IV. Representative Data

1. Claudin18.2/NCI-N87

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