| 名稱 | BRAF p.G466V Reference Standard 標(biāo)準(zhǔn)品 |
| 型號 | CBP10239 |
| 報價 | 900 |
| 特點 | BRAF p.G466V Reference Standard |
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電話：4008750250
號碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10239BRAF p.G466V Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
CBP10239 | |
| Format | Genomic DNA |
| Description | BRAF G466V lies within the protein kinase domain of the Braf protein (UniProt.org). G466V results in impaired Braf kinase activity, but paradoxically activates MEK and ERK through transactivation of CRAF in cell culture (PMID: 22649091, PMID: 28783719), and in one of two cell lines, G466V decreased cell proliferation and cell viability as compared to wild-type Braf (PMID: 29533785). |
| Technical Data | |
| DNA Change | c.1397G>T |
| AA Change | p.G466V |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | ENST00000288602 |
| Cosmic ID | COSM451 |
| Chr position(GRCh37) | chr7:140481411 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
