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聯(lián)系人：蔣經(jīng)理
電話：4008750250
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手機：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com

CBP71394
I. Background
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase.

II. Introduction
Host Cell:	CHO
Stability:	20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	F12k+10%FBS+5ug/ml puromycin+5ug/ml blasticidin
Mycoplasma Status:	Negative
Storage:	Liquid nitrogen immediately upon delivery
Application(s):	Functional assay for CCR2 receptor

Ⅲ. Description of Host Cell Line
Organism:	Hamster
Tissue:	Ovary
Morphology:	Epithelial
Growth Properties:	Adherent

Ⅳ. Representative Data
Figure 1. Recombinant CCR2/β-Arrestin/CHO constitutively expressing CCR2.
Figure 2. Dose response of Human CCL2 in CCR2 β-Arrestin CHO Cell Line (C10).
Figure 3.Inhibition of hCCL2-induced Beta-Arrestin Recruitment By CCL2 Neutralization Ab in CCR2 Beta-Arrestin CHO Cells(C10).