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聯(lián)系人：蔣經(jīng)理
電話：4008750250
號碼：
手機：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com

名稱	c-Kit D816H/BaF3
型號	CBP73282
報價
特點	c-Kit D816H/BaF3,母細胞：BaF3，凍存條件：90% FBS+10% DMSO；KIT D816H 位于 Kit 蛋白（PMID：19164557）的酪氨酸激酶結構域區(qū)域 2（外顯子 17）內(nèi)。 D816H 導致激酶活性增加、組成型 Kit 磷酸化、Stat3 信號傳導激活和培養(yǎng)細胞轉化，并賦予對某些 Kit 抑制劑的抗性。

CBP73282
I. Introduction
Cell Line Name：	c-Kit D816H/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application:	Anti-proliferation assay and PD assay
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative

II.Background
KIT D816H lies within the tyrosine kinase domain region 2 (exon 17) of the Kit protein (PMID: 19164557). D816H results in increased kinase activity, constitutive Kit phosphorylation, activation of Stat3 signaling, and transformation of cultured cells (PMID: 10362788, PMID: 11494148), and confers resistance to some Kit inhibitors (PMID: 25239608).

III. Representative Data
1. WB of c-Kit D816H/BaF3
2. Sanger of c-Kit D816H/BaF3
3. Anti-proliferation assay Figure 3. CTG Proliferation Assay of BaF3 C-KlT D816H.